Studying land use change and its associated climate effects is important to understand the role of human activities in the regulation of climate systems. By coupling remote sensing measurements with a high-resolution regional climate model, this study evaluated the land surface changes and corresponding climate impact caused by planting rice on saline-alkali land in western Jilin (China). Our results showed that paddy field expansion became the dominant land use change in western Jilin from 2015 to 2019, 25% of which was converted from saline-alkali land; this percentage is expected to increase in the near future. We found that saline-alkali land reclamation to paddy fields significantly increased the leaf area index (LAI), particularly in July and August, whereas it decreased albedo, mainly in May and June. Our simulation results showed that planting rice on saline-alkali land can help decrease the air temperature and increase the relative humidity. The temperature and humidity effects showed different magnitudes during the growing season and were most significant in July and August, followed by September and June. The nonradiative process, rather than the radiative process, played a dominant role in regulating the regional climate in this case, and the biophysical competition between evapotranspiration (ET) and albedo determined the temperature and relative humidity response differences during the growing season.